Synthesis and SAR evaluation of oxadiazolopyrazines as selective Haemophilus influenzae antibacterial agents.
Bioorg Med Chem Lett
; 13(19): 3133-6, 2003 Oct 06.
Article
em En
| MEDLINE
| ID: mdl-12951079
ABSTRACT
The parallel synthesis and antibacterial activity of 5-hydroxy[1,2,5] oxadiazolo[3,4-b]pyrazines is reported. The compounds were synthesized by condensing diaminofurazan with alpha-keto acids to give a variety of aryl-substituted analogues. Halogenated phenyl groups at C-6 give rise to the greatest Haemophilus influenzae antibacterial activity.
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Base de dados:
MEDLINE
Assunto principal:
Oxidiazóis
/
Pirazinas
/
Haemophilus influenzae
/
Antibacterianos
Idioma:
En
Ano de publicação:
2003
Tipo de documento:
Article