Lipid peroxidation in skeletal muscle of obese as compared to endurance-trained humans: a case of good vs. bad lipids?
FEBS Lett
; 551(1-3): 104-6, 2003 Sep 11.
Article
em En
| MEDLINE
| ID: mdl-12965212
ABSTRACT
Intra-myocellular triglycerides (IMTG) accumulate in the muscle of obese and endurance-trained (ET) humans and are considered a pathogenic factor in the development of insulin resistance, in the former. We postulate that this paradox may be associated with the peroxidation status of the IMTG. IMTG content was the same in the obese and ET subjects. The lipid peroxidation/IMTG ratio was 4.2-fold higher in the obese subjects. Hence, obesity results in an increased level of IMTG peroxidation while ET has a protective effect on IMTG peroxidation. This suggests a link between the lipid peroxidation/IMTG ratio and insulin resistance.
Buscar no Google
Base de dados:
MEDLINE
Assunto principal:
Resistência Física
/
Triglicerídeos
/
Músculo Esquelético
/
Obesidade
Idioma:
En
Ano de publicação:
2003
Tipo de documento:
Article