The angiotensin AT2 receptor modulates T-type calcium current in non-differentiated NG108-15 cells.
FEBS Lett
; 309(2): 161-4, 1992 Sep 07.
Article
em En
| MEDLINE
| ID: mdl-1324194
ABSTRACT
We report here that angiotensin II (AII) and the AT2 receptor-selective ligand, CGP 42112, modulate the T-type calcium current in non-differentiated NG108-15 cells, which express only AT2 receptors. Both peptides decrease the T-type calcium current at membrane potentials above -40 mV and shift the current-voltage curve at lower potentials with maximal effect between 5 and 10 min after application. These data describe a new cellular response to AII and suggest that the AT2 receptor mediates certain neurophysiological actions of this hormone.
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Base de dados:
MEDLINE
Assunto principal:
Angiotensina II
/
Receptores de Angiotensina
/
Cálcio
/
Neurônios
Idioma:
En
Ano de publicação:
1992
Tipo de documento:
Article