Prolongation of allograft and xenograft survival in mice by anti-CD2 monoclonal antibodies.
Transplantation
; 54(2): 286-91, 1992 Aug.
Article
em En
| MEDLINE
| ID: mdl-1353913
ABSTRACT
Anti-CD2 monoclonal antibodies (mAb) were used to influence graft survival in two transplantation models. Xenogeneic rat islets were transplanted intraportally into mice. Anti-CD2 mAb prolonged xenograft survival and was synergistic with UVB irradiation in prolonging survival. Anti-CD2 mAb was also more potent than an anti-CD4 mAb in this model. Allogeneic cardiac grafts were transplanted across an entire H-2 difference and anti-CD2 mAb prolonged allograft survival in a dose-dependent fashion. Kinetic experiments revealed that anti-CD2 mAb was most potent when administered at the time of allografting. A delay in administration of mAb markedly reduced its immunosuppressive effects. Furthermore, additional doses of mAb given after the initial doses provided no increased immunosuppression and anti-CD2 mAbs did not delay rejection of second-set allografts. These findings support the notion that anti-CD2 mAbs interfere with afferent immunity and that CD2 is most important during the initial steps of an immune response. Investigation of the effect of anti-CD2 mAb on cellular immune functions demonstrated, in agreement with previous results, that it caused antigenic down-modulation of CD2 with relative sparing of CD3, CD4, and CD8 cell surface expression. Concomitantly the MLR, CTL, and NK responses were suppressed.
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Base de dados:
MEDLINE
Assunto principal:
Receptores Imunológicos
/
Antígenos de Diferenciação de Linfócitos T
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Transplante das Ilhotas Pancreáticas
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Subpopulações de Linfócitos
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Transplante de Coração
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Terapia de Imunossupressão
Idioma:
En
Ano de publicação:
1992
Tipo de documento:
Article