Cholinergic agonists and interleukin 1 regulate processing and secretion of the Alzheimer beta/A4 amyloid protein precursor.
Proc Natl Acad Sci U S A
; 89(21): 10075-8, 1992 Nov 01.
Article
em En
| MEDLINE
| ID: mdl-1359534
ABSTRACT
Activation of protein kinase C by phorbol esters is known to accelerate the processing and secretion of the beta/A4 amyloid protein precursor. We have now examined various first messengers that increase protein kinase C activity of target cells for their ability to affect beta/A4 amyloid protein precursor metabolism. Acetylcholine and interleukin 1, which are altered in Alzheimer disease, were shown to increase processing of the beta/A4 amyloid protein precursor via the secretory cleavage pathway. Cholinergic agonists stimulated secretion in human glioma and neuroblastoma cells as well as in PC12 cells transfected with the M1 receptor, while interleukin 1 stimulated secretion in human endothelial and glioma cells.
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Base de dados:
MEDLINE
Assunto principal:
Parassimpatomiméticos
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Proteína Quinase C
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Endotélio Vascular
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Dibutirato de 12,13-Forbol
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Peptídeos beta-Amiloides
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Interleucina-1
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Precursor de Proteína beta-Amiloide
Idioma:
En
Ano de publicação:
1992
Tipo de documento:
Article