Effects of human, rat and porcine galanins on cardiac vagal action and blood pressure in the anaesthetised cat.
Neurosci Lett
; 136(1): 105-8, 1992 Feb 17.
Article
em En
| MEDLINE
| ID: mdl-1378950
ABSTRACT
Galanin (GAL) is distributed in sympathetic nerves in the cat, and exogenous GAL inhibits cardiac vagal action and lowers blood pressure in this species. This study on anaesthetised cats compares the effects on cardiac vagal action and blood pressure of human, rat and porcine GAL. Human GAL has only recently been sequenced. It is of particular interest as it is not C-terminally amidated, unlike porcine and rat GAL. Many regulatory peptides require a C-terminal amide group for their action. However, human GAL showed similar biological activity to the other (amidated) GALs here. Omission of a single amino acid (Ser6) from rat GAL significantly attenuated both cardiovascular actions studied here.
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Base de dados:
MEDLINE
Assunto principal:
Peptídeos
/
Nervo Vago
/
Pressão Sanguínea
/
Sistema de Condução Cardíaco
Idioma:
En
Ano de publicação:
1992
Tipo de documento:
Article