[Study of possible biological transformation of kanamycin to amikacin]. / Issledovanie vozmozhnosti biologicheskoi transformatsii kanamitsina v amikatsin.
Antibiot Khimioter
; 37(6): 10-2, 1992 Jun.
Article
em Ru
| MEDLINE
| ID: mdl-1384450
ABSTRACT
For transformation of kanamycin A (Km) to amikacin (Ak) with acylating enzymes from B. circulans, a culture producing butirosin (Btn), cellular and acellular conversion systems and methods for chemical and biological identification of Km, Ak and Btn were developed. The level of conversion of Km to Ak in vivo and in vitro did not exceed 2 per cent.
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Base de dados:
MEDLINE
Assunto principal:
Bacillus
/
Amicacina
/
Canamicina
/
Mutação
Idioma:
Ru
Ano de publicação:
1992
Tipo de documento:
Article