Urinary C3dg and C5b-9 indicate active immune disease in human membranous nephropathy.
Kidney Int
; 41(4): 933-7, 1992 Apr.
Article
em En
| MEDLINE
| ID: mdl-1387434
ABSTRACT
We have measured complement activation markers, C3dg and C5b-9 in plasma and urine from patients with idiopathic membranous nephropathy and IgA nephropathy. There was no significant difference in levels of plasma C5b-9 between the patient groups. However, high plasma concentrations of C3dg were associated significantly with IgA nephropathy with 45% of patients having levels over 25 U/ml (P less than 0.001). High concentrations of urinary C3dg and C5b-9 were associated significantly with membranous nephropathy (43% and 43% of the patient group, respectively) compared to patients with IgA nephropathy (10% and 0%, respectively, P less than 0.001). In a retrospective analysis of 31 patients with membranous nephropathy, 66% of patients with high initial urinary C5b-9 showed an unstable clinical course compared to 18% of patients with initially absent or low C5b-9 (P less than 0.001). We suggest that high urinary C5b-9 identifies those patients with a membranous lesion which retains an active immunological component contributing to the pathology of progressive glomerular damage.
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Base de dados:
MEDLINE
Assunto principal:
Receptores de Complemento
/
Glomerulonefrite Membranosa
/
Complexo de Ataque à Membrana do Sistema Complemento
/
Doenças do Sistema Imunitário
Idioma:
En
Ano de publicação:
1992
Tipo de documento:
Article