Determination of AJ-3941, a possible agent for the treatment of cerebrovascular disorders, in plasma and brain by means of high-performance liquid chromatography with fluorescence detection.
J Chromatogr
; 578(1): 152-6, 1992 Jul 01.
Article
em En
| MEDLINE
| ID: mdl-1400782
ABSTRACT
A sensitive and selective high-performance liquid chromatographic method with fluorescence detection is described for the determination of AJ-3941 (I), a possible agent for the treatment of cerebrovascular disorders, in plasma and brain tissue. A simple hexane extraction was used for plasma, and for brain homogenate the hexane extract was further purified by solid-phase extraction. The determination limit was ca. 3 ng/ml for both plasma (0.5 ml) and 10% (w/v) brain homogenate (1 ml). The method was applied to the determination of I in plasma and brain samples of experimental animals.
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Base de dados:
MEDLINE
Assunto principal:
Piperazinas
/
Dibenzoxepinas
Idioma:
En
Ano de publicação:
1992
Tipo de documento:
Article