Quantitative study of the precancerous and malignant lesions in colorectal adenomas.
Pathol Res Pract
; 188(4-5): 561-4, 1992 Jun.
Article
em En
| MEDLINE
| ID: mdl-1409089
ABSTRACT
150 endoscopically removed colorectal adenomas are quantitatively studied. In 90 cases dysplastic glands constituted the entire lesion (30 mild, 30 moderate, 30 severe); in 60 cases foci of adenocarcinoma were present (30 intramucosal, 30 submucosal). In each case the area, the perimeter and the integrated optical density of 100 nuclei were measured from Feulgen-stained paraffin sections. The results show a continuous neoplastic progression in the trends of the morphometric parameters as well as in the ploidy pattern. The stepwise discriminant analysis defined the morphometric features of the atypical nuclei, which were present in small numbers also in mild dysplasia; they progressively increased in number, reaching the maximum in submucosal carcinoma.
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Base de dados:
MEDLINE
Assunto principal:
Lesões Pré-Cancerosas
/
Neoplasias Colorretais
/
Adenocarcinoma
/
Adenoma
Idioma:
En
Ano de publicação:
1992
Tipo de documento:
Article