Immunolocalization of two cytochrome P450 isozymes in rat nasal chemosensory tissue.
Neuroreport
; 3(9): 749-52, 1992 Sep.
Article
em En
| MEDLINE
| ID: mdl-1421130
ABSTRACT
The NMa and NMb isoforms of cytochrome P450 enzymes are expressed in three nasal chemosensory organs the olfactory, septal and vomeronasal mucosae. The NMa isoform is widely distributed throughout the nasal mucosa whereas the NMb isoform is present primarily in the chemosensory mucosae. The localization of cytochromes P450 demonstrates that sustentacular cells in the olfactory and septal epithelia, the mucus of the vomeronasal organ and the acinar cells of glands in the lamina propria of all three chemosensory systems engage in xenobiotic metabolism and participate in odorant/pheromone clearance, a perireceptor process associated with chemosensory transduction.
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Base de dados:
MEDLINE
Assunto principal:
Mucosa Olfatória
/
Sistema Enzimático do Citocromo P-450
/
Isoenzimas
/
Mucosa Nasal
/
Septo Nasal
Idioma:
En
Ano de publicação:
1992
Tipo de documento:
Article