Mutations of the Ki-ras oncogene in endometrial carcinoma.
Am J Obstet Gynecol
; 167(1): 227-32, 1992 Jul.
Article
em En
| MEDLINE
| ID: mdl-1442931
ABSTRACT
OBJECTIVE:
The purpose of this study was to assess the extent of involvement of the ras oncogene in endometrial carcinoma. STUDYDESIGN:
Genomic deoxyribonucleic acid from 30 samples of endometrial carcinoma was examined for point mutations in codons 12, 13, and 61 from the Ha-ras, Ki-ras, and N-ras genes by means of the polymerase chain reaction, slot-blotting, and deoxyribonucleic acid sequencing procedures.RESULTS:
An apparent somatic mutation of Ki-ras codon 12 in one of 10 paraffin-embedded tumors was confirmed by deoxyribonucleic acid sequence analysis. Two of 20 frozen endometrial carcinoma specimens were also shown to contain a point mutation in Ki-ras codon 12. No correlation between ras mutation and a number of histologic or clinical parameters was observed.CONCLUSIONS:
These data suggest a potential role for Ki-ras codon 12 mutations in the development of some (10%) endometrial cancers.
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Base de dados:
MEDLINE
Assunto principal:
Genes ras
/
Neoplasias do Endométrio
/
Mutação Puntual
Idioma:
En
Ano de publicação:
1992
Tipo de documento:
Article