Advanced hemostatic dressing development program: animal model selection criteria and results of a study of nine hemostatic dressings in a model of severe large venous hemorrhage and hepatic injury in Swine.
J Trauma
; 55(3): 518-26, 2003 Sep.
Article
em En
| MEDLINE
| ID: mdl-14501897
ABSTRACT
BACKGROUND:
An advanced hemostatic dressing is needed to augment current methods for the control of life-threatening hemorrhage. A systematic approach to the study of dressings is described. We studied the effects of nine hemostatic dressings on blood loss using a model of severe venous hemorrhage and hepatic injury in swine.METHODS:
Swine were treated using one of nine hemostatic dressings. Dressings used the following primary active ingredients microfibrillar collagen, oxidized cellulose, thrombin, fibrinogen, propyl gallate, aluminum sulfate, and fully acetylated poly-N-acetyl glucosamine. Standardized liver injuries were induced, dressings were applied, and resuscitation was initiated. Blood loss, hemostasis, and 60-minute survival were quantified.RESULTS:
The American Red Cross hemostatic dressing (fibrinogen and thrombin) reduced (p < 0.01) posttreatment blood loss (366 mL; 95% confidence interval, 175-762 mL) and increased (p < 0.05) the percentage of animals in which hemostasis was attained (73%), compared with gauze controls (2,973 mL; 95% confidence interval, 1,414-6,102 mL and 0%, respectively). No other dressing was effective. The number of vessels lacerated was positively related to pretreatment blood loss and negatively related to hemostasis.CONCLUSION:
The hemorrhage model allowed differentiation among topical hemostatic agents for severe hemorrhage. The American Red Cross hemostatic dressing was effective and warrants further development.
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Base de dados:
MEDLINE
Assunto principal:
Bandagens
/
Hemostáticos
/
Técnicas Hemostáticas
/
Modelos Animais de Doenças
/
Hemorragia
/
Fígado
Idioma:
En
Ano de publicação:
2003
Tipo de documento:
Article