Possible relationship between streptococcal pyrogenic exotoxin A and Kawasaki syndrome in patients older than six months of age.
Pediatr Infect Dis J
; 22(9): 794-8, 2003 Sep.
Article
em En
| MEDLINE
| ID: mdl-14506370
ABSTRACT
BACKGROUND:
We previously investigated antibody titers against four kinds of superantigens [streptococcal pyrogenic exotoxin A (SPEA), streptococcal pyrogenic exotoxin C, toxic shock syndrome toxin-1 and staphylococcal enterotoxin B] in patients with Kawasaki syndrome (KS) younger than 6 months of age and reported a relationship between toxic shock syndrome toxin-1 and KS patients. In this study we have investigated antibody titers in KS patients older than 6 months of age.METHODS:
Serum of 81 patients with KS older than 6 months of age, before intravenous gamma-globulin therapy, and 88 normal age-matched children were used in this study. The IgG antibody titers against four kinds of superantigens were measured with an enzyme-linked immunosorbent assay.RESULTS:
The KS patients showed significantly elevated mean SPEA titer (P = 0.006) and significantly higher incidence of high SPEA (P = 0.0024) compared with the controls. The SPEA titer in KS patients showed a significant positive correlation with the number of days from onset of illness (P = 0.0002).CONCLUSIONS:
The elevated antibody titer against superantigens of KS patients older than 6 months of age was different from that of KS patients younger than 6 months of age. Our results suggest that KS patients' exposure to SPEA occurred a few weeks before the onset of KS. SPEA may be one of the possible etiologic agents of KS among patients older than 6 months of age in Kagoshima, Japan.
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Base de dados:
MEDLINE
Assunto principal:
Pirogênios
/
Staphylococcus
/
Superantígenos
/
Exotoxinas
/
Anticorpos Antibacterianos
/
Síndrome de Linfonodos Mucocutâneos
Idioma:
En
Ano de publicação:
2003
Tipo de documento:
Article