Blood oxygen level-dependent magnetic resonance imaging in patients with stress-induced angina.
Circulation
; 108(18): 2219-23, 2003 Nov 04.
Article
em En
| MEDLINE
| ID: mdl-14557359
ABSTRACT
BACKGROUND:
Blood oxygen level-dependent (BOLD) MRI reflects tissue oxygenation and may be useful for the detection of myocardial ischemia in patients with suspected coronary artery disease. METHODS ANDRESULTS:
We studied 25 patients with stress-induced angina using a T2*-sensitive echo planar imaging sequence before and during adenosine in a single-slice approach. BOLD-MRI results were compared with quantitative angiography and adenosine thallium single-photon emission computed tomography (SPECT). Although image quality was variable because of artifacts, no data were excluded from the analysis. During adenosine, a mean signal intensity decrease was observed for myocardial segments related to coronary stenoses >75%. On average, a nonsignificant increase was observed in the other segments. The angiographically determined stenosis was correlated with BOLD-MRI results. Including all segments and using BOLD-MRI signal intensity increase cutoff value of 1.2%, BOLD-MRI had a sensitivity of 88% and a specificity of 47% to correctly classify severe stenoses. Adenosine thallium SPECT data from distal segments of the same coronary territory were also correlated with BOLD-MRI. However, variability was substantial.CONCLUSIONS:
In patients with stress-induced angina, adenosine BOLD-MRI detects myocardial ischemia in myocardial segments related to severe coronary stenoses. Its potential will increase with additional improvement of spatial coverage and image quality.
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Base de dados:
MEDLINE
Assunto principal:
Oxigênio
/
Estresse Fisiológico
/
Imageamento por Ressonância Magnética
/
Angina Pectoris
Idioma:
En
Ano de publicação:
2003
Tipo de documento:
Article