[Clinical observation of the efficacy of navelbine combined with ifosfamide and cisplatin in the treatment of advanced breast cancer].

OBJECTIVE: To observe the efficacy of navelbine combined with ifosfamide and cisplatin in the treatment of advanced breast cancer. METHODS: Forty cases of pathologically confirmed stages III-IV breast cancer were treated with combined chemotherapy including intravenously infused navelbine (25 mg/m2, days 1 and 8), ifosfamide (1.3 g/m2, days 1 to 5) and cisplatin (20 mg/m2, days 1-5), administered in cycles of 21 days. The therapeutic effect was assessed after at least two cycles were completed. RESULTS: Complete remission was achieved in 6 cases and partial remission in 16, with an overall responding rate of 55%. The main toxicity was bone marrow suppression manifested by grades III-IV leukopenia occurring at a rate of 40%. CONCLUSION: Navelbine in combination with ifosfamide and cisplatin is effective and safe in the treatment of advanced breast cancer.