Synthesis and biological evaluation of S-acyl-3-thiopropyl prodrugs of N-phosphonoacetyl-L-aspartate (PALA).
Eur J Med Chem
; 38(10): 883-91, 2003 Oct.
Article
em En
| MEDLINE
| ID: mdl-14575935
ABSTRACT
The synthesis of new prodrugs of PALA characterised by the presence of S-acyl-3-thiopropyl, as enzyme-labile groups on the phosphonate moiety of PALA, is reported. The cytotoxic activities of PALA prodrugs were determined against human cell line (SW1573 lung carcinoma cells). A number of prodrugs bearing S-pivaloyl as acyl groups displayed cytotoxic activity in the same order of magnitude of PALA.
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Base de dados:
MEDLINE
Assunto principal:
Ácido Fosfonoacéticos
/
Pró-Fármacos
/
Ácido Aspártico
/
Antineoplásicos
Idioma:
En
Ano de publicação:
2003
Tipo de documento:
Article