Serine/threonine protein phosphatases PP1 and PP2A are key players in apoptosis.
Biochimie
; 85(8): 721-6, 2003 Aug.
Article
em En
| MEDLINE
| ID: mdl-14585537
ABSTRACT
The reversible phosphorylation of proteins controlled by protein kinases and protein phosphatases is a major mechanism that regulates a wide variety of cellular processes. In contrast to C. elegans, recent studies in mammalian cells have highlighted a major role of serine/threonine protein phosphorylation in apoptosis. To illustrate the importance of dephosphorylation processes in apoptosis, this review will focus on recent studies suggesting that the interaction of the serine/threonine protein phosphatase 1 (PP1) and protein phosphatase 2A (PP2A) with certain regulators of the Bcl-2 family is critically involved in the control of apoptosis.
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Base de dados:
MEDLINE
Assunto principal:
Proteínas Serina-Treonina Quinases
/
Apoptose
/
Fosfoproteínas Fosfatases
Idioma:
En
Ano de publicação:
2003
Tipo de documento:
Article