Pharmacokinetics of ivermectin in the yak (Bos grunniens).
Vet Parasitol
; 117(1-2): 153-7, 2003 Nov 03.
Article
em En
| MEDLINE
| ID: mdl-14597289
ABSTRACT
The yak (Bos grunniens) belongs to the cattle family Bovidae and lives in the mountains of China and adjacent areas. Due to the physiological adaptations of yak to its environment and the lack of data, the ivermectin pharmacokinetic was studied following a single subcutaneous dose at the recommended dose for cattle (0.2 mg kg(-1)). The observed peak plasma concentration (Cmax) was 48.93 ng ml(-1) and the time to reach Cmax (Tmax) was 0.73 day. These results show a faster rate of absorption than in cattle. The values for the absorption half-life (t(1/2a)), the distribution half-life (t(1/2alpha)) and the terminal half-life (t(1/2beta)) were 0.31, 0.74 and 4.82 days, respectively. The calculated area under the concentration-time curve (AUC) was 146.2 ng day ml(-1) and the mean residence time (MRT) was 3.57 days. The availability of ivermectin appears low in yaks in comparison to cattle but equivalent to that reported in horses and is likely to be due to physiological characteristics of this species.
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Base de dados:
MEDLINE
Assunto principal:
Ivermectina
/
Bovinos
/
Anti-Helmínticos
Idioma:
En
Ano de publicação:
2003
Tipo de documento:
Article