Expression of nitric oxide synthases in keratinocytes after UVB irradiation.
Arch Dermatol Res
; 295(7): 293-6, 2003 Dec.
Article
em En
| MEDLINE
| ID: mdl-14615895
ABSTRACT
The importance of nitric oxide (NO) in mediating vasodilation, neurotransmission, and immune and inflammatory responses has been demonstrated. Human keratinocyte express inducible nitric oxide synthase (iNOS) and the neuronal constitutive isoform of NOS (ncNOS). We established an in vitro model in keratinocytes to investigate changes in NO, iNOS and ncNOS expression after UVB exposure. We demonstrated a large induction of NO after UVB exposure and that the source of NO produced in UVB-exposed keratinocytes was increased expression of iNOS and ncNOS. The increased NO production with increased expression of iNOS and ncNOS may contribute to the pathological and physiological features of UVB-induced erythema and skin inflammation.
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Base de dados:
MEDLINE
Assunto principal:
Raios Ultravioleta
/
Queratinócitos
/
Óxido Nítrico Sintase
Idioma:
En
Ano de publicação:
2003
Tipo de documento:
Article