Postoperative confusion in schizophrenic patients is affected by interleukin-6.
J Clin Anesth
; 15(6): 455-62, 2003 Sep.
Article
em En
| MEDLINE
| ID: mdl-14652125
ABSTRACT
STUDY OBJECTIVE:
To investigate whether epidural analgesia with local anesthetics affects postoperative confusion in schizophrenic patients or the relationships between cortisol or interleukin-6 (IL-6) and postoperative confusion.DESIGN:
Prospective, randomized study.SETTING:
Hakodate Watanabe Hospital and Hirosaki National Hospital. PATIENTS 105 patients who were scheduled to undergo abdominal surgery with general anesthesia.INTERVENTIONS:
The schizophrenic patients were rendomly divided into two groups patients in Group A received epidural anesthesia and patients in Group B did not receive epidural anesthesia. MEASUREMENTS AND MAINRESULTS:
Postoperative confusion during the first 48 hours after the end of operation occurred in 7 of 33 patients (21%) in Group A and 10 of 33 patients (30%) in Group B. There were no significant differences in the frequency of postoperative confusion between Groups A and B. Plasma cortisol concentrations in schizophrenic patients in Group A were significantly lower 15 minutes after incision and the end of surgery than those levels of patients in Group B; however, there was no significant difference between groups in plasma cortisol concentrations after anesthesia. Plasma IL-6 concentrations (51.7 +/- 22.0 and 31.4 +/- 8.2 pg mL(-1)) in patients with postoperative confusion at the end of surgery and 24 hours after surgery were significantly higher than those levels (34.4 +/- 16.2 and 16.9 +/- 7.7 pg mL(-1)) in patients without postoperative confusion.CONCLUSIONS:
Epidural anesthesia does not significantly decrease the frequency of postoperative confusion in schizophrenic patients. Plasma IL-6 concentrations at the end of the operation and 24 hours after surgery in schizophrenic patients with postoperative confusion were significantly higher than those concentrations in patients without postoperative confusion.
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Base de dados:
MEDLINE
Assunto principal:
Complicações Pós-Operatórias
/
Esquizofrenia
/
Interleucina-6
/
Confusão
/
Anestesia Epidural
Idioma:
En
Ano de publicação:
2003
Tipo de documento:
Article