Morphological development of microglia in the postnatal rat brain. A quantitative study.
Int J Dev Neurosci
; 21(8): 445-50, 2003 Dec.
Article
em En
| MEDLINE
| ID: mdl-14659995
ABSTRACT
Morphological transformation of lectin-positive microglia/macrophages in the developing rat cerebral hemisphere was analysed using quantitative methods. During the first postnatal month, the cells showed increases in their size and fractal dimension accompanied by a simultaneous decrease in their solidity. Regional variations in dynamics of the process indicated the existence of spatio-temporal developmental gradients within the cerebral hemisphere wall which might correspond with regional patterns of neuronal differentiation. Results of the present study prove that the quantitative methods can be the source of reliable data replacing subjective cell typologies.
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Base de dados:
MEDLINE
Assunto principal:
Encéfalo
/
Envelhecimento
/
Microglia
/
Tamanho Celular
Idioma:
En
Ano de publicação:
2003
Tipo de documento:
Article