Age-related changes of the multidrug resistance P-glycoprotein function in normal human peripheral blood T lymphocytes.
Braz J Med Biol Res
; 36(12): 1653-7, 2003 Dec.
Article
em En
| MEDLINE
| ID: mdl-14666249
ABSTRACT
The multidrug resistance P-glycoprotein is a transmembrane efflux pump expressed by lymphocytes and is involved in their cytolytic activity. In the present study, we investigated the age-related changes of P-glycoprotein function in normal peripheral blood lymphocytes. Blood samples from 90 normal volunteers (age range, 0 to 86 years) were analyzed. P-glycoprotein function was assessed by the flow cytometric rhodamine 123 assay. P-glycoprotein function was highest in cord blood and progressively declined with age in peripheral blood T CD4+ and CD8+ cells. In contrast, P-glycoprotein function did not vary with age in CD19+ B or CD16+CD56+ natural killer cells. These data suggest that the decline in P-glycoprotein function in T CD4+ and CD8+ lymphocytes as a function of age may contribute to the decrease in T cell cytolytic activity with aging.
Buscar no Google
Base de dados:
MEDLINE
Assunto principal:
Linfócitos T
/
Membro 1 da Subfamília B de Cassetes de Ligação de ATP
/
Resistência a Múltiplos Medicamentos
Idioma:
En
Ano de publicação:
2003
Tipo de documento:
Article