[Effectiveness of passive immunisation against respiratory syncytium virus in a group of premature infants with birth weight below 1000 grams]. / Ocena skutecznosci stosowania uodpornienia biernego przeciwko wirusom syncytium nablonka oddechowego (RSV) preparatem Synagis w grupie wczesniakow z masa urodzeniowa ciala ponizej 1000 gramow.
Ginekol Pol
; 74(10): 1154-9, 2003 Oct.
Article
em Pl
| MEDLINE
| ID: mdl-14669411
ABSTRACT
Respiratory syncytial virus (RSV) is a major cause of respiratory tract infection during the child's first year of life. Those who survive neonatal intensive care are commonly rehospitalized. In the absence of vaccine, passive immunoprophylaxis is the preferred approach. Safety and efficacy of Palivizumab (Synagis) was proven in the Impact-RSV Trial, conducted in the USA, Canada and UK. The aim of the study was to determine efficacy of humanized monoclonal RSV antibody in prematures infants born 25-32 week gestation with weight birth below 1000 g with and without broncho-pulmonary dysplasia. We compared the hospitalization rates and morbidity between two groups of children who received palivizumab and without any protection. We confirm the efficacy and safety of Synagis. The outcome of this study supports the use of palivizumab prophylaxis in high-risk children.
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Base de dados:
MEDLINE
Assunto principal:
Antivirais
/
Vírus Sinciciais Respiratórios
/
Imunização Passiva
/
Infecções por Vírus Respiratório Sincicial
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Recém-Nascido de muito Baixo Peso
/
Doenças do Prematuro
/
Anticorpos Monoclonais
Idioma:
Pl
Ano de publicação:
2003
Tipo de documento:
Article