Fourier transform ion cyclotron resonance mass spectrometry using atmospheric pressure photoionization for high-resolution analyses of corticosteroids.
Rapid Commun Mass Spectrom
; 17(24): 2763-8, 2003.
Article
em En
| MEDLINE
| ID: mdl-14673824
ABSTRACT
Fourier transform ion cyclotron resonance mass spectrometry (FTICRMS) was coupled with atmospheric pressure photoionization (APPI) for the first time and used for the analysis of several corticosteroids.1 The analytes showed excellent response using APPI when compared with both electrospray ionization (ESI) and atmospheric pressure chemical ionization (APCI). APPI has the advantage of requiring less heat for desolvation, resulting in less thermal degradation of the analytes and higher signal-to-noise than APCI. In terms of ultimate sensitivity, APPI is more efficient than either ESI or APCI for the analysis of corticosteroids. With some compounds, the high-resolution capability of FTICRMS was necessary to obtain an accurate mass due to contributions of the M(+.) (13)C isotope in the [M+H](+) ion peak.
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Base de dados:
MEDLINE
Assunto principal:
Fotoquímica
/
Corticosteroides
/
Espectroscopia de Infravermelho com Transformada de Fourier
/
Espectrometria de Massas por Ionização por Electrospray
Idioma:
En
Ano de publicação:
2003
Tipo de documento:
Article