Autoantibodies to interferon-gamma in a patient with selective susceptibility to mycobacterial infection and organ-specific autoimmunity.
Clin Infect Dis
; 38(1): e10-4, 2004 Jan 01.
Article
em En
| MEDLINE
| ID: mdl-14679469
ABSTRACT
We evaluated a patient with disseminated Mycobacterium tuberculosis and Mycobacterium chelonae infection, of which he died. He also developed autoimmune (type I) diabetes and primary hypothyroidism. His serum contained a high titer of immunoglobulin G autoantibody to interferon-gamma (IFN-gamma) capable of blocking in vitro responses to this cytokine by peripheral blood mononuclear cells from normal donors. These results suggest that autoantibodies to IFN-gamma can induce susceptibility to disseminated mycobacterial infection, which may be refractory to chemotherapy.
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Base de dados:
MEDLINE
Assunto principal:
Autoanticorpos
/
Tuberculose
/
Imunoglobulina G
/
Interferon gama
/
Infecções por Mycobacterium não Tuberculosas
Idioma:
En
Ano de publicação:
2004
Tipo de documento:
Article