Congenital Rosai-Dorfman disease without lymphadenopathy.
Pediatr Pathol Mol Med
; 22(5): 399-403, 2003.
Article
em En
| MEDLINE
| ID: mdl-14692191
ABSTRACT
Rosai-Dorfman disease (RDD) is a rare histiocytic proliferative disorder with massive lymphadenopathy. We here describe RDD of a neonate who presented with paleness and hepatosplenomegaly but not lymph-node swelling. Routine laboratory studies showed anemia, thrombocytopenia, and an elevated value of gamma-glutamyl transpeptidase. Histological examination of the liver revealed a proliferation of histiocytes with abundant eosinophilic cytoplasm, which were positive for S-100 protein and CD68 but not CD1a and did not reveal Birbeck granules. Radiological studies showed hepatosplenomegaly and a narrowing of the hepatic vein, which might have contributed to hypersplenism resulting in anemia and thrombocytopenia. This case is thought to be congenital RDD without lymphadenopathy.
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Base de dados:
MEDLINE
Assunto principal:
Histiocitose Sinusal
/
Doenças Linfáticas
Idioma:
En
Ano de publicação:
2003
Tipo de documento:
Article