Ataxia-telangiectasia-mutated (ATM) gene in head and neck squamous cell carcinoma: promoter hypermethylation with clinical correlation in 100 cases.
Cancer Epidemiol Biomarkers Prev
; 13(1): 150-6, 2004 Jan.
Article
em En
| MEDLINE
| ID: mdl-14744748
ABSTRACT
The Ataxia-telangiectasia-mutated (ATM) gene product is a well-characterized tumor suppressor that plays a key role in maintenance of genomic stability. We have recently documented that the ATM promoter is a target for epigenetic silencing in cultured tumor cells. Here we show that aberrant methylation of the ATM promoter occurs in a significant percentage (25%) of head and neck squamous cell carcinomas. The presence of methylated ATM promoter shows a statistically significant correlation with an earlier age of initial diagnosis and decreased overall survival, particularly in early-stage tumors. These findings indicate that ATM promoter hypermethylation occurs in head and neck squamous cell carcinoma, and this feature is a potentially useful prognostic marker in this tumor type.
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Base de dados:
MEDLINE
Assunto principal:
Ataxia Telangiectasia
/
Carcinoma de Células Escamosas
/
Regiões Promotoras Genéticas
/
Neoplasias de Cabeça e Pescoço
Idioma:
En
Ano de publicação:
2004
Tipo de documento:
Article