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SDF-1 (CXCL12) is upregulated in the ischemic penumbra following stroke: association with bone marrow cell homing to injury.
Hill, William D; Hess, David C; Martin-Studdard, Angeline; Carothers, Jo J; Zheng, Jianqing; Hale, David; Maeda, Manabu; Fagan, Susan C; Carroll, James E; Conway, Simon J.
Afiliação
  • Hill WD; Department of Cellular Biology and Anatomy, Medical College of Georgia, Augusta, Georgia 30912-2000, USA. whill@mail.mcg.edu
J Neuropathol Exp Neurol ; 63(1): 84-96, 2004 Jan.
Article em En | MEDLINE | ID: mdl-14748564
The chemokine stromal-derived factor-1 (SDF-1, also known as CXCL12) and its receptor CXCR4 have been implicated in homing of stem cells to the bone marrow and the homing of bone marrow-derived cells to sites of injury. Bone marrow cells infiltrate brain and give rise to long-term resident cells following injury. Therefore, SDF-1 and CXCR4 expression patterns in 40 mice were examined relative to the homing of bone marrow-derived cells to sites of ischemic injury using a stroke model. Mice received bone marrow transplants from green fluorescent protein (GFP) transgenic donors and later underwent a temporary middle cerebral artery suture occlusion (MCAo). SDF-1 was associated with blood vessels and cellular profiles by 24 hours through at least 30 days post-MCAo. SDF-1 expression was principally localized to the ischemic penumbra. The majority of SDF-1 expression was associated with reactive astrocytes; much of this was perivascular. GFP+ cells were associated with SDF-1-positive vessels and were also found in the neuropil of regions with increased SDF-1 immunoreactivity. Most vessel-associated GFP+ cells resemble pericytes or perivascular microglia and the majority of the GFP+ cells in the parenchyma displayed characteristics of activated microglial cells. These findings suggest SDF-1 is important in the homing of bone marrow-derived cells, especially monocytes, to areas of ischemic injury.
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Base de dados: MEDLINE Assunto principal: Movimento Celular / Isquemia Encefálica / Transplante de Medula Óssea / Quimiocinas CXC Idioma: En Ano de publicação: 2004 Tipo de documento: Article
Buscar no Google
Base de dados: MEDLINE Assunto principal: Movimento Celular / Isquemia Encefálica / Transplante de Medula Óssea / Quimiocinas CXC Idioma: En Ano de publicação: 2004 Tipo de documento: Article