Antitussive activity of the tachykinin NK1 receptor antagonist, CP-99994, in dogs.
Eur J Pharmacol
; 485(1-3): 329-32, 2004 Feb 06.
Article
em En
| MEDLINE
| ID: mdl-14757157
ABSTRACT
CP-99994 [(+)-(2S,3S)-3-(2-methoxybenzylamino)-2-phenylpiperidine] is a selective tachykinin NK(1) receptor antagonist that inhibits cough in guinea pigs and cats. This study examined the antitussive effects of CP-99994 in dogs produced by mechanical stimulation of the intrathoracic trachea. CP-99994 (10 mg/kg, p.o.) inhibited cough frequency by 52% at 2 h, 31% at 6 h and by 21% at 24 h. Cough amplitude was inhibited by 45% at 6 h but unchanged at 2 and 24 h after CP-99994. Plasma levels of CP-99994 were highest at 2 h (75+/-26 ng/ml) and fell to 22+/-6 ng/ml at 6 h. These results demonstrate antitussive activity of CP-99994 in dogs at a dose proven to antagonize tachykinin NK(1) receptors in this species.
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Base de dados:
MEDLINE
Assunto principal:
Antitussígenos
/
Piperidinas
/
Tosse
/
Antagonistas dos Receptores de Neurocinina-1
Idioma:
En
Ano de publicação:
2004
Tipo de documento:
Article