Efficient microwave assisted synthesis of optically active bicyclic 2-pyridinones via delta2-thiazolines.
Mol Divers
; 7(2-4): 165-9, 2003.
Article
em En
| MEDLINE
| ID: mdl-14870846
ABSTRACT
A new efficient synthesis of optically active bicyclic 2-pyridiones has been developed using microwave irradiation. The synthesis is a two-step procedure via delta2-thiazolines, which only requires a 3 + 2 min reaction time compared to 2 days when using conventional heating. The optimized conditions proved to be suitable for the synthesis of a small library in excellent yields and with limited racemizations.
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Base de dados:
MEDLINE
Assunto principal:
Piridonas
/
Tiazóis
/
Química Orgânica
/
Micro-Ondas
Idioma:
En
Ano de publicação:
2003
Tipo de documento:
Article