Tolerance-induced receptor selection: scope, sensitivity, locus specificity, and relationship to lymphocyte-positive selection.
Immunol Rev
; 197: 219-30, 2004 Feb.
Article
em En
| MEDLINE
| ID: mdl-14962198
ABSTRACT
Receptor editing is a mode of immunological tolerance of B lymphocytes that involves antigen-induced B-cell receptor signaling and consequent secondary immunoglobulin light chain gene recombination. This ongoing rearrangement often changes B-cell specificity for antigen, rendering the cell non-autoreactive and sparing it from deletion. We currently believe that tolerance-induced editing is limited to early stages in B-cell development and that it is a major mechanism of tolerance, with a low-affinity threshold and the potential to take place in virtually every developing B cell. The present review highlights the contributions from our laboratory over several years to elucidate these features.
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Base de dados:
MEDLINE
Assunto principal:
Linfócitos B
/
Receptores de Antígenos de Linfócitos B
/
Rearranjo Gênico de Cadeia Leve de Linfócito B
/
Tolerância a Antígenos Próprios
Idioma:
En
Ano de publicação:
2004
Tipo de documento:
Article