Epidemiologic study on the origin of cancer after kidney transplantation.
Transplantation
; 77(3): 426-8, 2004 Feb 15.
Article
em En
| MEDLINE
| ID: mdl-14966419
ABSTRACT
BACKGROUND:
Subjects who underwent solid organ transplantation are at higher risk for a wide variety of cancers.METHODS:
The authors investigated the origin of cancer in a cohort of 2,526 patients followed up for 60.7 +/- 35.6 months after kidney transplantation between 1990 and 2000 in seven transplant centers.RESULTS:
One hundred four of them developed cancer. All subjects who developed solid cancer within 6 months after transplantation (n=10) and a group of subjects who developed solid cancer after 6 months posttransplant (n=10) were selected. Short tandem repeat analysis was performed on paraffin-embedded biopsy specimens of tumors and on both donor and recipient pretransplant peripheral blood. Biologic material was obtained in 17 of the 20 selected patients (85.0%). The analysis showed that 16 of 17 tumors were genetically identical to the recipient.CONCLUSIONS:
The authors' results suggest that donor transmission of solid cancer is an unlikely event in their population.
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Base de dados:
MEDLINE
Assunto principal:
Transplante de Órgãos
/
Neoplasias
Idioma:
En
Ano de publicação:
2004
Tipo de documento:
Article