[Aortitis after G-CSF injections]. / Aortite après injections de G-CSF.
Rev Med Interne
; 25(3): 225-9, 2004 Mar.
Article
em Fr
| MEDLINE
| ID: mdl-14990294
ABSTRACT
INTRODUCTION:
Aortitis consists in aortic wall inflammation from infectious or non infectious cause. It may lead to aortic aneurysm with a risk of rupture, which is life-threatening and may justify surgical procedures. The cause of the aortitis is sometimes obscure. CASE REPORT We report the case of a 55 years old woman who developed acute aortitis of the descending aorta after G-CSF (granulocyte-colony stimulating factor) injections for blood stem cells graft. No cause was found to the aortitis, the evolution was favorable after corticosteroid treatment, without aneurysm at six months.CONCLUSION:
The present case rises the question of G-CSF (Neupogen responsibility in aortic lesions. Neutrophilic mediated diseases (Sweet's syndrome, pyoderma gangrenosum) and leukocytoclastic vasculitis were reported after G-CSF therapy. Neutrophils induced by G-CSF injections present functional abnormalities which may play a role in the pathogenesis of these diseases.
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Base de dados:
MEDLINE
Assunto principal:
Aortite
/
Fator Estimulador de Colônias de Granulócitos
Idioma:
Fr
Ano de publicação:
2004
Tipo de documento:
Article