Regulation of feeding by galnon.
Neuropeptides
; 38(1): 55-61, 2004 Feb.
Article
em En
| MEDLINE
| ID: mdl-15003717
ABSTRACT
Galanin is a neuropeptide that has been implicated in multiple bioactivities, inter alia eating disorders. In this study, we have examined the effects of galnon, a novel low molecular weight galanin receptor ligand. Previous studies have shown that galnon acts as a systemically active, blood-brain barrier crossing agonist on galanin signaling both in vitro and in vivo, inhibiting pentylenetetrazole-induced seizures. Here, intracerebroventricular (10-20 microg) and intraperitoneal (1.5-5 mg/kg) administration of galnon induced a strong, dose-dependent reduction of food intake in rats and mice. This reduction in feeding occurred without reducing general activity and was shown to be attenuated by an intracerebroventricular administration of M35, a peptide galanin antagonist. These data demonstrate that galnon is a promising tool for studies of the involvement of galanin in feeding disorders and other behavioral processes.
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Base de dados:
MEDLINE
Assunto principal:
Bradicinina
/
Galanina
/
Cumarínicos
/
Ingestão de Alimentos
Idioma:
En
Ano de publicação:
2004
Tipo de documento:
Article