Exacerbation of soft tissue lesions in lead exposed virus infected mice.
Biomed Environ Sci
; 16(4): 369-78, 2003 Dec.
Article
em En
| MEDLINE
| ID: mdl-15011968
ABSTRACT
OBJECTIVE:
To investigate the effect of Lead (Pb) acetate exposure on Semliki forest virus (SFV) pathogenesis in mice.METHODS:
Different doses (62.5, 125, 250 and 500 mg/Kg body weight) of Pb dissolved in normal saline were given to mice by oral intubation in a sub-acute (28 days) and sub-chronic (90 days) regimen followed by SFV infection. Morbidity, mortality, clinical symptoms, mean survival time (MST), changes in body and organ weight, accumulation of lead in soft tissues, virus titre in brain and histopathological alterations were compared between lead exposed and infected groups.RESULTS:
Early appearance of virus symptoms, increased mortality, decreased MST, enhanced SFV titre and greater tissue damage were observed in lead exposed-SFV-infected mice.CONCLUSION:
Pre-exposure to lead increases the susceptibility of mice towards SFV infection. Further studies are suggested in view of the persistence of lead in the environment and the possibility of infection by microbial pathogens.
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Base de dados:
MEDLINE
Assunto principal:
Vírus da Floresta de Semliki
/
Encéfalo
/
Infecções por Alphavirus
/
Rim
/
Chumbo
/
Fígado
Idioma:
En
Ano de publicação:
2003
Tipo de documento:
Article