[Sequence polymorphisms of the mitochondrial DNA control region in 100 Chengdu Hans in China].
Zhonghua Yi Xue Yi Chuan Xue Za Zhi
; 21(2): 144-8, 2004 Apr.
Article
em Zh
| MEDLINE
| ID: mdl-15079797
ABSTRACT
OBJECTIVE:
To study the genetic polymorphisms of the mitochondrial DNA (mtDNA) control region in Chengdu Han population.METHODS:
Sequence polymorphisms of the mtDNA control region, hypervariable regions I and II from 100 unrelated Chinese Hans were determined by PCR and direct sequencing.RESULTS:
Sequences of 404 nucleotides for hypervariable region I and 379 nucleotides for region II were obtained. Ninety-two and fifty variable sites were revealed in region I and region II respectively as compared to the reference sequence, and a total of 97 different genetic patterns from both the regions I and II were determined. The probability of identity was estimated at 1.84% for region I, 1.94% for region II, and 1.18% for both the regions.CONCLUSION:
These results suggest that sequence polymorphism of mtDNA control region would be very useful in forensic practice as a marker for individual identification.
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Base de dados:
MEDLINE
Assunto principal:
Polimorfismo Genético
/
DNA Mitocondrial
Idioma:
Zh
Ano de publicação:
2004
Tipo de documento:
Article