Radical carboxyarylation approach to lignans. Total synthesis of (-)-arctigenin, (-)-matairesinol, and related natural products.
Org Lett
; 6(9): 1345-8, 2004 Apr 29.
Article
em En
| MEDLINE
| ID: mdl-15101738
ABSTRACT
[reaction see text] Total syntheses of seven biologically important lignan natural products, including (-)-arctigenin, (-)-matairesinol, and (-)-alpha-conidendrin, by way of a highly stereoselective domino radical sequence is presented. The reported stereochemistry of the natural product 7-hydroxyarctigenin is shown to be erroneous; a diastereoisomeric structure is assigned to the natural product.
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Base de dados:
MEDLINE
Assunto principal:
Tetra-Hidronaftalenos
/
Produtos Biológicos
/
Lignanas
/
Furanos
Idioma:
En
Ano de publicação:
2004
Tipo de documento:
Article