c-Fos expression in the spinal cord of female rats with artificial ureteric calculosis.
Neurosci Lett
; 361(1-3): 212-5, 2004 May 06.
Article
em En
| MEDLINE
| ID: mdl-15135931
ABSTRACT
Rats with an artificial stone in the left ureter display spontaneous pain behavior (ureteral 'crises') and referred hyperalgesia/contraction in the ipsilateral oblique musculature. To evaluate neuronal activation in both sensitive and motor pathways in this model, c-Fos expression was studied in the spinal cord of calculosis rats vs. sham controls. Fos-labeled cells were never observed in sham controls. In stone rats, they were found in the T10-L2 segments, throughout the dorsal horn, significantly more on the left than the right side (P < 0.002). Fos-labeled cells were also found in lamina IX, containing motoneurons; at the T11-T12 level, these were significantly more on the left than the right side (P < 0.03). Nociceptive input from the ureter thus activates not only sensory but also efferent neurons in the spinal cord, suggesting the triggering of reflex arcs by the visceral focus.
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Base de dados:
MEDLINE
Assunto principal:
Medula Espinal
/
Ureter
/
Cálculos Ureterais
/
Proteínas Proto-Oncogênicas c-fos
/
Fibras Aferentes Viscerais
/
Neurônios Aferentes
Idioma:
En
Ano de publicação:
2004
Tipo de documento:
Article