Chromosome damaging effects of pan masala.
Cancer Lett
; 65(3): 221-6, 1992 Aug 31.
Article
em En
| MEDLINE
| ID: mdl-1516036
ABSTRACT
Effects of aqueous extracts of a popular brand of pan masala with and without tobacco (PM-T and PM) were studied for short duration treatment employing an in vitro system. Metabolic activation with S9 mix was also included. Frequency of all the three cytogenetic endpoints viz., chromosome aberration (CA); sister chromatid exchange (SCE) and % micronucleated cells (% MNC) were found to be elevated significantly in a dose-dependent manner in cultures without metabolic activation. However, addition of S9 activation system resulted in suppression of chromosomal damage. Our findings indicate that pan masalas contain water soluble direct acting mutagens.
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Base de dados:
MEDLINE
Assunto principal:
Areca
/
Plantas Medicinais
/
Troca de Cromátide Irmã
/
Extratos Vegetais
/
Aberrações Cromossômicas
/
Mutagênicos
Idioma:
En
Ano de publicação:
1992
Tipo de documento:
Article