Regulators of G protein signaling: potential drug targets for controlling cardiovascular and immune function.
Curr Drug Targets Immune Endocr Metabol Disord
; 4(2): 107-18, 2004 Jun.
Article
em En
| MEDLINE
| ID: mdl-15180451
ABSTRACT
Heterotrimeric G-protein-coupled receptors (GPCRs) mediate a wide variety of organismal functions ranging from vision, olfaction, and gustation to the development and physiology of the cardiovascular, neuronal, and immune system. Naturally they are targets of a large number of therapeutic drugs. The regulators of G protein signaling (RGS) are a family of diverse proteins that regulate the GPCR-mediated signaling pathways principally by acting as GTPase activating proteins (GAPs) for the alpha subunit of the heterotrimeric G-proteins. Certain members of the RGS family contain multiple domains and motifs that mediate interactions with other signaling molecules, thus linking GPCR-dependent and GPCR-independent signaling pathways. Because of their ability to fine-tune vital GPCR-mediated processes and recent findings linking them to brain disorders, retinitis pigmentosa, and cancer RGS proteins have become excellent candidates for new drug discovery. The focus of this review is to discuss the roles of the RGS proteins in the development and normal physiology of cardiovascular and immune system, and to explore their potential as drug targets useful for the treatment of pathological conditions of the cardiovascular and immune systems.
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Base de dados:
MEDLINE
Assunto principal:
Doenças Cardiovasculares
/
Sistemas de Liberação de Medicamentos
/
Reguladores de Proteínas de Ligação ao GTP
/
Imunidade
Idioma:
En
Ano de publicação:
2004
Tipo de documento:
Article