Synthesis and structure-activity relationship of novel benzoxazole derivatives as melatonin receptor agonists.
Bioorg Med Chem Lett
; 14(14): 3799-802, 2004 Jul 16.
Article
em En
| MEDLINE
| ID: mdl-15203165
ABSTRACT
A series of benzoxazole derivatives was synthesized and evaluated as melatoninergic ligands. The binding affinity of these compounds for human MT(1) and MT(2) receptors was determined using 2-[(125)I]-iodomelatonin as the radioligand. From this series of benzoxazole derivatives, compounds 14 and 17 were identified as melatonin receptor agonists.
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Base de dados:
MEDLINE
Assunto principal:
Benzoxazóis
/
Receptores de Melatonina
Idioma:
En
Ano de publicação:
2004
Tipo de documento:
Article