Platelet MAO-B activity and vitamin B12 in old age dementias.
Mol Chem Neuropathol
; 16(1-2): 23-32, 1992.
Article
em En
| MEDLINE
| ID: mdl-1520404
ABSTRACT
Platelet MAO-B activity, serum vitamin B12 levels, and plasma folate were measured in patients suffering from presenile (AD) and senile (SDAT) dementia of Alzheimer-type, and vascular dementia (VD). MAO-B was higher in the SDAT group than in AD and controls. An inverse relationship between MAO-B activity and vit. B12 levels was documented in the whole group and in each category studied; furthermore, MAO-B was positively related to age. All the patients were then divided into two groups, according to vit. B12 levels (Group I less than 200 pg/mL; Group II greater than or equal to 200 pg/mL); Group I showed a significantly higher MAO-B activity with respect to Group II. The results indicate the existence of a negative association between platelet MAO-B activity and serum levels of vitamin B12 and confirm the existence of biological differences between presenile and senile dementia of Alzheimer type.
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Base de dados:
MEDLINE
Assunto principal:
Vitamina B 12
/
Demência Vascular
/
Doença de Alzheimer
/
Monoaminoxidase
Idioma:
En
Ano de publicação:
1992
Tipo de documento:
Article