High-performance liquid chromatographic determination of the pi values of azol-N-yl substituents.
J Pharm Sci
; 81(6): 577-80, 1992 Jun.
Article
em En
| MEDLINE
| ID: mdl-1522498
ABSTRACT
The pi (hydrophobic constant) values for 16 parent azoles (pyrrole, imidazole, pyrazole, four triazoles, two tetrazoles, indole, benzimidazole, 1H- and 2H-indazoles, 1H- and 2H-benzotriazoles, and carbazole) were calculated from the logarithms of the capacity factors (log k') determined by HPLC. The values thus obtained are discussed according to an additive model in which the number and position of pyridinelike nitrogen atoms and the annelation effect are considered.
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Base de dados:
MEDLINE
Assunto principal:
Azóis
Idioma:
En
Ano de publicação:
1992
Tipo de documento:
Article