Theoretical study on the selectivity of asymmetric sulfur ylide epoxidation reaction.
Org Lett
; 6(15): 2559-62, 2004 Jul 22.
Article
em En
| MEDLINE
| ID: mdl-15255690
ABSTRACT
[structure see text] We report the first theoretical studies on the asymmetric sulfonium ylide epoxidation reaction using a chiral sulfide that successfully reproduces the experimentally determined high enantiomeric excess. Calculations at the DFT level suggest that the transition states for the addition of the sulfonium ylide to benzaldehyde have energies which account for the observed enantioselectivity.
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Base de dados:
MEDLINE
Idioma:
En
Ano de publicação:
2004
Tipo de documento:
Article