[Mifepristone combined with methotrexate for conservative treatment of tubal ectopic pregnancy].

ABSTRACT

OBJECTIVE: To observe the effects of mifepristone combined with methotrexate for conservative treatment of tubal ectopic pregnancy. METHODS: A total of 102 cases of tubal ectopic pregnancy diagnosed at early stage were enrolled to receive oral mefepristone at the dose of 75 mg twice daily for 3 d and intramuscular injection with calcium leucovorin at 0.1 mg/kg 24 h after a single dose of methotrexate injection (1 mg/kg.b.w.). In the control group consisting of 86 similar cases, intramuscular injection with calcium leucovorin at 0.1 mg/kg was given 24 h after a single dose of methotrexate (1 mg/kg.b.w.). RESULTS: Ninety-four of the 102 cases ( 92.20%) receiving oral mifepristone combined with calcium leucovorin and methotrexate were cured, a curative rate significantly higher than that in the control group, where 70 cases (81.4%) were cured (P<0.05). CONCLUSION: Mefepristone combined with methotrexate is safe and effective in the treatment of tubal ectopic pregnancy, without obvious side effects.