Synthesis of an immunosuppressant SQAG9 and determination of the binding peptide by T7 phage display.
Bioorg Med Chem Lett
; 14(16): 4343-6, 2004 Aug 16.
Article
em En
| MEDLINE
| ID: mdl-15261299
ABSTRACT
SQAG9, a new class of immunosuppressive sulfoquinovosylacylglycerol, and its biotinylated derivatives have been synthesized. A T7 Phage library, composed of random cDNA fragments from Drosophila melanogaster, displayed a possible binding peptide of 14 amino acids. The immobilized synthetic peptide on a sensor chip showed a dissociation constant of K(D)=1.5 x 10(-6) against SQAG9 in a surface plasmon resonance experiment.
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Base de dados:
MEDLINE
Assunto principal:
Peptídeos
/
Glicolipídeos
/
Bacteriófago T7
/
Imunossupressores
Idioma:
En
Ano de publicação:
2004
Tipo de documento:
Article