P1' oxadiazole protease inhibitors with excellent activity against native and protease inhibitor-resistant HIV-1.
Bioorg Med Chem Lett
; 14(18): 4651-4, 2004 Sep 20.
Article
em En
| MEDLINE
| ID: mdl-15324882
ABSTRACT
HIV-1 protease inhibitors (PI's) bearing 1,3,4-oxadiazoles at the P1' position were prepared by a novel method involving the diastereoselective installation of a carboxylic acid and conversion to the P1' heterocycle. The compounds are picomolar inhibitors of native HIV-1 protease, with most of the compounds maintaining excellent antiviral activity against a panel of PI-resistant strains.
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Base de dados:
MEDLINE
Assunto principal:
Oxidiazóis
/
HIV-1
/
Inibidores da Protease de HIV
Idioma:
En
Ano de publicação:
2004
Tipo de documento:
Article