Interleukin-6: effects on and production by rat granulosa cells in vitro.
Endocrinology
; 130(3): 1750-2, 1992 Mar.
Article
em En
| MEDLINE
| ID: mdl-1537322
ABSTRACT
Treatment of FSH-stimulated granulosa cells with increasing amounts of interleukin-6 (IL-6) caused a significant concentration-dependent suppression of progesterone biosynthesis. However, basal progesterone production in non-FSH-stimulated cells remained unresponsive to the cytokine. Quantitation of IL-6 in the conditioned media from untreated granulosa cells by the 7TD1 hybridoma cell bioassay revealed detectable levels of IL-6. Further, FSH treatment caused a significant concentration-dependent increase in IL-6 release. In contrast, both basal and FSH-stimulated IL-6 release could be significantly suppressed by interferon gamma (INF-gamma). The results of the present study suggest 1) a role for IL-6 in the regulation of progesterone production, 2) that the granulosa cell is a source of IL-6 and 3) that the release of IL-6 by the granulosa cell is a regulated event.
Buscar no Google
Base de dados:
MEDLINE
Assunto principal:
Interleucina-6
/
Células da Granulosa
Idioma:
En
Ano de publicação:
1992
Tipo de documento:
Article