Novel selective and potent 5-HT reuptake inhibitors with 5-HT1D antagonist activity: chemistry and pharmacological evaluation of a series of thienopyran derivatives.
Bioorg Med Chem
; 12(20): 5277-95, 2004 Oct 15.
Article
em En
| MEDLINE
| ID: mdl-15388156
ABSTRACT
A series of compounds combining the naphthylpiperazine and thienopyran scaffolds has been prepared and evaluated for 5-HT reuptake inhibition with 5-HT1D antagonist activity. The design of these compounds has been based on the 'overlapping type' strategy where two pharmacophores are linked in a single molecule. The resultant dual pharmacological profile has the potential to deliver a more efficient treatment for depression.
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Base de dados:
MEDLINE
Assunto principal:
Piranos
/
Antagonistas da Serotonina
/
Inibidores Seletivos de Recaptação de Serotonina
/
Antagonistas do Receptor 5-HT1 de Serotonina
Idioma:
En
Ano de publicação:
2004
Tipo de documento:
Article